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An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium

ABSTRACT: Normal human bronchial epithelial cells were studied under four different conditions: control, pressure 30 cmH2O, AG1478 (1 microM), and pressure plus AG1478 at 1, 3, and 8 hours, all in the absence of exogenous EGF. Keywords: Normal human bronchial epithelial cells. Time series under 4 different stimuli with no replicate measurements.

ORGANISM(S): Homo sapiens

SUBMITTER: Alvin Kho

PROVIDER: E-GEOD-19500 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium.

Kojic Nikola N Chung Euiheon E Kho Alvin T AT Park Jin-Ah JA Huang Austin A So Peter T C PT Tschumperlin Daniel J DJ

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100107 5

The mechanical landscape in biological systems can be complex and dynamic, with contrasting sustained and fluctuating loads regularly superposed within the same tissue. How resident cells discriminate between these scenarios to respond accordingly remains largely unknown. Here, we show that a step increase in compressive stress of physiological magnitude shrinks the lateral intercellular space between bronchial epithelial cells, but does so with strikingly slow exponential kinetics (time constan ...[more]

PMID: 20056713

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