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Histone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes [ChIP-seq]

ABSTRACT: The molecular signature at histone H3K4 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3 and H3K4ac histone modification associated with active chromatin to provide an understanding of the changes in epigenetic regulation associated with the unique breast cancer subtypes. H3K4me3 and H3K4ac histone modification study in normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology

ORGANISM(S): Homo sapiens

SUBMITTER: Joe Boyd

PROVIDER: E-GEOD-69377 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes.

Messier Terri L TL Gordon Jonathan A R JA Boyd Joseph R JR Tye Coralee E CE Browne Gillian G Stein Janet L JL Lian Jane B JB Stein Gary S GS

Oncotarget 20160201 5

The onset and progression of breast cancer are linked to genetic and epigenetic changes that alter the normal programming of cells. Epigenetic modifications of DNA and histones contribute to chromatin structure that result in the activation or repression of gene expression. Several epigenetic pathways have been shown to be highly deregulated in cancer cells. Targeting specific histone modifications represents a viable strategy to prevent oncogenic transformation, tumor growth or metastasis. Meth ...[more]

PMID: 26783963

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