Genomics

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Bivalency - Histone H3 Lysine4 and Histone H3 Lysine27 Methylation Dynamics


ABSTRACT: The molecular signature at histone H3K4me3 and H3K27me3 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3, associated with active chromatin, and H3K27me3, associated with repressed chromatin, histone modifications to provide an understanding of the changes in epigenetic regulation associated with the unique breast cancer subtypes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE77772 | GEO | 2016/03/24

SECONDARY ACCESSION(S): PRJNA311514

REPOSITORIES: GEO

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