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Bivalency - Histone H3 Lysine4 and Histone H3 Lysine27 Methylation Dynamics

ABSTRACT: The molecular signature at histone H3K4me3 and H3K27me3 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3, associated with active chromatin, and H3K27me3, associated with repressed chromatin, histone modifications to provide an understanding of the changes in epigenetic regulation associated with the unique breast cancer subtypes. histone H3K4me3 and H3K27me3 ChIP-seq normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells Please note that the 'H3K4me3' and 'input' data are duplicated records of the samples represented in GSE69377 for the convenient retrieval of the complete raw data from SRA.

ORGANISM(S): Homo sapiens

SUBMITTER: Joe Boyd

PROVIDER: E-GEOD-77772 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oncofetal Epigenetic Bivalency in Breast Cancer Cells: H3K4 and H3K27 Tri-Methylation as a Biomarker for Phenotypic Plasticity.

Messier Terri L TL Boyd Joseph R JR Gordon Jonathan A R JA Stein Janet L JL Lian Jane B JB Stein Gary S GS

Journal of cellular physiology 20160310 11

Alterations in the epigenetic landscape are fundamental drivers of aberrant gene expression that contribute to cancer progression and pathology. Understanding specific modes of epigenetic regulation can be used to identify novel biomarkers or targets for therapeutic intervention to clinically treat solid tumors and leukemias. The bivalent marking of gene promoters by H3K4me3 and H3K27me3 is a primary mechanism to poise genes for expression in pluripotent embryonic stem cells (ESC). In this study ...[more]

PMID: 26916849

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Histone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes [ChIP-seq]

Project description:The molecular signature at histone H3K4 involved in epigenetic regulation of normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology. This study examines the dynamic distribution of H3K4me3 and H3K4ac histone modification associated with active chromatin to provide an understanding of the changes in epigenetic regulation associated with the unique breast cancer subtypes. H3K4me3 and H3K4ac histone modification study in normal (MCF10A) and transformed (MCF7, MDA-MB-231) breast cells using ChIP-Seq technology

2016-02-10 | E-GEOD-69377 | biostudies-arrayexpress

Histone H3 lysine 4 acetylation-methylation dynamics define breast cancer subtypes [RNA-seq]

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2016-02-10 | E-GEOD-75168 | biostudies-arrayexpress

Bivalency - Histone H3 Lysine4 and Histone H3 Lysine27 Methylation Dynamics

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2016-03-24 | GSE77772 | GEO

Histone H3 Lysine4 Acetylation-Methylation Dynamics Define Breast Cancer Subtypes [ChIP-seq]

2016-02-10 | GSE69377 | GEO

Differential Gene Expression between MCF10A and MCF7 cells

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PARP-1, H3 and H3K4me3 ChIP-chip from MCF7 cells

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Phosphoproteomic analysis of breast cancer-derived extracellular vesicles reveals disease-specific phosphorylated enzymes

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2022-02-28 | PXD030424 | Pride

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