Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Expression data from Lineage-c-Kit+Sca-1+ (LSK) and megakaryocyte/erythroid progenitor (MEP) cells isolated from WT, Ezh2?/?, JAK2V617F, and JAK2V617F/Ezh2?/? mice


ABSTRACT: Loss-of-function mutations in EZH2 are associated with worse outcomes in patients with primary myelofibrosis (PMF). To understand how EZH2 insufficiency is involved in the pathogenesis of PMF, we generated mice compound for Ezh2 conditional deletion and a JAK2V617F transgene. The total bone marrow cells isolated from Cre-ERT2, Ezh2flox/flox;Cre-ERT2, JAK2V617F;Cre-ERT2 and JAK2V617F;Ezh2flox/flox;Cre-ERT2 mice were transplanted into lethally irradiated CD45.1+ wild-type recipient mice. As we deleted Ezh2 at four weeks post transplantation, we performed gene-expression analysis of LSKs and MEPs isolated from the recipient mice at 2 months post transplantation.

ORGANISM(S): Mus musculus

SUBMITTER: Goro Sashida 

PROVIDER: E-GEOD-69498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2015-06-04 | E-GEOD-69499 | biostudies-arrayexpress
2015-06-04 | GSE69498 | GEO
2015-06-04 | GSE69499 | GEO
2013-09-27 | E-GEOD-42705 | biostudies-arrayexpress
2013-09-04 | E-GEOD-50537 | biostudies-arrayexpress
2013-07-23 | E-GEOD-41812 | biostudies-arrayexpress
2023-07-20 | PXD041265 | Pride
2015-02-04 | E-GEOD-60660 | biostudies-arrayexpress
2020-02-17 | PXD014451 | Pride
2016-06-24 | E-GEOD-82072 | biostudies-arrayexpress