Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kirby Dean Johnson
PROVIDER: E-GEOD-6958 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Johnson Kirby D KD Boyer Meghan E ME Kang Jeong-Ah JA Wickrema Amittha A Cantor Alan B AB Bresnick Emery H EH
Blood 20070305 12
The GATA-1-interacting protein Friend Of GATA-1 (FOG-1) is essential for the proper transcriptional activation and repression of numerous GATA-1 target genes. Although FOG-1-independent activation by GATA-1 has been described, all known examples of GATA-1-mediated repression are FOG-1 dependent. In the GATA-1-null G1E cell line, estrogen receptor ligand binding domain (ER) chimeras of either wild-type GATA-1 or a FOG-1-binding defective mutant of GATA-1 repressed several genes similarly upon act ...[more]