Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Timothy Chlon
PROVIDER: E-GEOD-35644 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chlon Timothy M TM Doré Louis C LC Crispino John D JD
Molecular cell 20120705 4
GATA-1 and its cofactor FOG-1 are required for the differentiation of erythrocytes and megakaryocytes. In contrast, mast cell development requires GATA-1 and the absence of FOG-1. Through genome-wide comparison of the chromatin occupancy of GATA-1 and a naturally occurring mutant that cannot bind FOG-1 (GATA-1(V205G)), we reveal that FOG-1 intricately regulates the chromatin occupancy of GATA-1. We identified GATA1-selective and GATA-1(V205G)-selective binding sites and show that GATA-1, in the ...[more]