Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Delong Liu
PROVIDER: E-GEOD-70926 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Saba Nakhle S NS Liu Delong D Herman Sarah E M SE Underbayev Chingiz C Tian Xin X Behrend David D Weniger Marc A MA Skarzynski Martin M Gyamfi Jennifer J Fontan Lorena L Melnick Ari A Grant Cliona C Roschewski Mark M Navarro Alba A Beà Sílvia S Pittaluga Stefania S Dunleavy Kieron K Wilson Wyndham H WH Wiestner Adrian A
Blood 20160428 1
To interrogate signaling pathways activated in mantle cell lymphoma (MCL) in vivo, we contrasted gene expression profiles of 55 tumor samples isolated from blood and lymph nodes from 43 previously untreated patients with active disease. In addition to lymph nodes, MCL often involves blood, bone marrow, and spleen and is incurable for most patients. Recently, the Bruton tyrosine kinase (BTK) inhibitor ibrutinib demonstrated important clinical activity in MCL. However, the role of specific signali ...[more]