Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Direct in vivo evidence for B-cell receptor and NF-KB activation in mantle cell lymphoma: role of the lymph node microenvironment and activating mutations. [Affymetrix]


ABSTRACT: We provide direct in vivo evidence for activation of the BCR and canonical NF-KB pathways in MCL that, in the absence of activating mutations, is dependent on the lymph node microenvironment. This finding provides a mechanistic explanation for the surprising efficacy of ibrutinib for the treatment of this type of lymphoma. Mutations in components of the BCR and NF-KB pathways are associated with cell-autonomous signaling and resistance to ibrutinib. Lymph node biopsies and peripheral blood samples were obtained from 55 patients with previously untreated MCL. The samples are distributed into 3 groups: peripheral blood (purified CD19, N=17), unpurified lymph node biopsy (mixed tissue biopsy, N=34), and purified lymph node (purified CD19 Tumor, N=4).

ORGANISM(S): Homo sapiens

SUBMITTER: Delong Liu 

PROVIDER: E-GEOD-70910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2016-07-15 | E-GEOD-70926 | biostudies-arrayexpress
2016-07-15 | GSE70910 | GEO
2016-07-15 | GSE70926 | GEO
2018-10-26 | PXD005734 | Pride
2018-07-10 | GSE116810 | GEO
2018-05-01 | GSE99276 | GEO
2011-10-25 | E-GEOD-26918 | biostudies-arrayexpress
2015-12-31 | E-GEOD-70651 | biostudies-arrayexpress
2024-02-19 | GSE227976 | GEO
2015-12-31 | GSE70651 | GEO