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Pancreatic Beta Cell Enhancers Regulate Rhythmic Transcription of Exocyst Triggering and Diabetes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Mark Perelis

PROVIDER: E-GEOD-70961 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.

Perelis Mark M Marcheva Biliana B Ramsey Kathryn Moynihan KM Schipma Matthew J MJ Hutchison Alan L AL Taguchi Akihiko A Peek Clara Bien CB Hong Heekyung H Huang Wenyu W Omura Chiaki C Allred Amanda L AL Bradfield Christopher A CA Dinner Aaron R AR Barish Grant D GD Bass Joseph J

Science (New York, N.Y.) 20151101 6261

The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior and metabolism with the solar cycle. Genetic or environmental perturbation of circadian cycles contributes to metabolic disorders including type 2 diabetes. To study the impact of the cell-autonomous clock on pancreatic β cell function, we examined pancreatic islets from mice with either intact or disrupted BMAL1 expression both throughout life and limited to adulthood. We ...[more]

PMID: 26542580

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