Dataset Information
Porcine liver
Ontology highlight
ABSTRACT:
ORGANISM(S): Sus scrofa
SUBMITTER: Yewon Cheon
PROVIDER: E-GEOD-714 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species.
American journal of physiology. Regulatory, integrative and comparative physiology 20050113 6
Peroxisome proliferator-activated receptor alpha (PPARalpha), a key regulator of fatty acid oxidation, is essential for adaptation to fasting in rats and mice. However, physiological functions of PPARalpha in other species, including humans, are controversial. A group of PPARalpha ligands called peroxisome proliferators (PPs) causes peroxisome proliferation and hepatocarcinogenesis only in rats and mice. To elucidate the role of PPARalpha in adaptation to fasting in nonproliferating species, we ...[more]
