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New targets of Drosophila adenosine deaminase acting on RNA (dADAR)

ABSTRACT: The aim of this experiment is to identify new targets of Drosophila adenosine deaminase acting on RNA (dADAR) by enriching Inosine-containing mRNA (I-mRNA) from wild type (C-S) and dADAR mutant flies and then hybridization with Drosophila cDNA arrays.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Gabriel Haddad

PROVIDER: E-GEOD-529 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of new targets of Drosophila pre-mRNA adenosine deaminase.

Xia Shuli S Yang Jinghua J Su Yingjun Y Qian Jiang J Ma Enbo E Haddad Gabriel G GG

Physiological genomics 20041102 2

Adenosine deaminase acting on RNA (ADAR) in Drosophila and mammals has recently become the target of numerous investigations. It is now clear that this protein has a number of functions in the nervous system. Indeed, the mutation of ADAR in Drosophila (dADAR) results in many pathological and physiological changes, such as sensitivity to hypoxia and neuronal degeneration. To understand the full scope of dADAR function, it is crucial to identify new dADAR targets. A polyclonal antibody against ino ...[more]

PMID: 15522950

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