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S. cerevisiae mutant with a constitutively activated Ras/cAMP pathway

ABSTRACT: Comparison of the transcriptomes of Saccharomyces cerevisiae wild type FY23 and a PDE2 deletion mutant DJ28. Keywords = PDE2 Keywords = Ras/cAMP pathway

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Dawn Jones

PROVIDER: E-GEOD-600 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome profiling of a Saccharomyces cerevisiae mutant with a constitutively activated Ras/cAMP pathway.

Jones D L DL Petty J J Hoyle D C DC Hayes A A Ragni E E Popolo L L Oliver S G SG Stateva L I LI

Physiological genomics 20031216 1

Often changes in gene expression levels have been considered significant only when above/below some arbitrarily chosen threshold. We investigated the effect of applying a purely statistical approach to microarray analysis and demonstrated that small changes in gene expression have biological significance. Whole genome microarray analysis of a pde2Delta mutant, constructed in the Saccharomyces cerevisiae reference strain FY23, revealed altered expression of approximately 11% of protein encoding g ...[more]

PMID: 14570984

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