Unknown,Transcriptomics,Genomics,Proteomics

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Long non-coding RNAs in B cells (ChIP-Seq)


ABSTRACT: Using RNA sequencing and de novo transcript assembly, we identified 4516 lncRNAs expressed in 8 different stages of B cell development and activation. Chromatin immuno-precipitation sequencing was used to classify a substantial fraction (38%) of these lncRNAs as enhancer-associated or promoter-associated RNAs (eRNAs or pRNAs). A catalogue of lncRNAs expressed in eight murine B cell populations

ORGANISM(S): Mus musculus

SUBMITTER: Jethro Johnson 

PROVIDER: E-GEOD-72017 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Long noncoding RNAs in B-cell development and activation.

Brazão Tiago F TF   Johnson Jethro S JS   Müller Jennifer J   Heger Andreas A   Ponting Chris P CP   Tybulewicz Victor L J VL  

Blood 20160705 7


Long noncoding RNAs (lncRNAs) are potentially important regulators of cell differentiation and development, but little is known about their roles in B lymphocytes. Using RNA-seq and de novo transcript assembly, we identified 4516 lncRNAs expressed in 11 stages of B-cell development and activation. Most of these lncRNAs have not been previously detected, even in the closely related T-cell lineage. Comparison with lncRNAs previously described in human B cells identified 185 mouse lncRNAs that have  ...[more]

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