Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hanseul Yang
PROVIDER: E-GEOD-72146 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
eLife 20151121
Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that dramatic shifts in large open-chromatin domain (super-enhancer) landscapes underlie these differences and reflect tumor microenvironment. By in vivo super-enhancer and transcriptional profiling, we uncover a dynamic cancer-specific epigenetic network selectively enriched for binding motifs of a transcription factor cohort expressed in squam ...[more]