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ETS Family Transcriptional Regulators Drive Chromatin Dynamics and Malignancy in Squamous Cell Carcinomas

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Hanseul Yang

PROVIDER: E-GEOD-72147 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas.

Yang Hanseul H Schramek Daniel D Adam Rene C RC Keyes Brice E BE Wang Ping P Zheng Deyou D Fuchs Elaine E

eLife 20151121

Tumor-initiating stem cells (SCs) exhibit distinct patterns of transcription factors and gene expression compared to healthy counterparts. Here, we show that dramatic shifts in large open-chromatin domain (super-enhancer) landscapes underlie these differences and reflect tumor microenvironment. By in vivo super-enhancer and transcriptional profiling, we uncover a dynamic cancer-specific epigenetic network selectively enriched for binding motifs of a transcription factor cohort expressed in squam ...[more]

PMID: 26590320

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