Ribosomal protein S3: a functional component of NF-kB p65 binding complexes
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Louis Staudt
PROVIDER: E-GEOD-7231 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.
Wan Fengyi F Anderson D Eric DE Barnitz Robert A RA Snow Andrew A Bidere Nicolas N Zheng Lixin L Hegde Vijay V Lam Lloyd T LT Staudt Louis M LM Levens David D Deutsch Walter A WA Lenardo Michael J MJ
Cell 20071101 5
NF-kappaB is a DNA-binding protein complex that transduces a variety of activating signals from the cytoplasm to specific sets of target genes. To understand the preferential recruitment of NF-kappaB to specific gene regulatory sites, we used NF-kappaB p65 in a tandem affinity purification and mass spectrometry proteomic screen. We identified ribosomal protein S3 (RPS3), a KH domain protein, as a non-Rel subunit of p65 homodimer and p65-p50 heterodimer DNA-binding complexes that synergistically ...[more]
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