Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Tarjei Mikkelsen
PROVIDER: E-GEOD-11483 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Meissner Alexander A Mikkelsen Tarjei S TS Gu Hongcang H Wernig Marius M Hanna Jacob J Sivachenko Andrey A Zhang Xiaolan X Bernstein Bradley E BE Nusbaum Chad C Jaffe David B DB Gnirke Andreas A Jaenisch Rudolf R Lander Eric S ES
Nature 20080706 7205
DNA methylation is essential for normal development and has been implicated in many pathologies including cancer. Our knowledge about the genome-wide distribution of DNA methylation, how it changes during cellular differentiation and how it relates to histone methylation and other chromatin modifications in mammals remains limited. Here we report the generation and analysis of genome-scale DNA methylation profiles at nucleotide resolution in mammalian cells. Using high-throughput reduced represe ...[more]