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CGH result of Neisseria meningitidis ST-7 isolates

ABSTRACT: Neisseria meningitidis is a major cause of bacterial meningitis and septicemia worldwide. Seven new serogroup C meningococci were isolated from two provinces of China in January, 2006. Their PorA VR types were P1.20, 9. Multilocus sequence typing results indicated that they all belonged to ST-7. It is a new serogroup C N. meningitidis sequence type clone identified in China. Here we also present the results of a genomic comparison of these isolates with other 15 N. meningitidis serogroup A and B isolates, which belonged to ST-7, based on comparative genomic hybridization analysis. The data described here would be helpful to monitor the spread of this new serogroup C meningococci sequence type clone in China and worldwide. Keywords: comparative genomic hybridization To compare the genome compositions of these menC ST-7 isolates with those of menC ST-4821 isolates, menA ST-7 isolates and menB ST-7 isolates, we performed comparative genomic hybridization (CGH) analysis among 17 N. meningitidis isolates (including two newly identified menC ST-7 isolates) using an updated version of the whole-genome microarray of N. meningitidis serogroup C isolate 053442 .

ORGANISM(S): Neisseria meningitidis

SUBMITTER: Junping Peng

PROVIDER: E-GEOD-7331 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Characterization of a new Neisseria meningitidis serogroup C clone from China.

Peng Junping J Zhang Xiaobing X Shao Zhujun Z Yang Li L Jin Qi Q

Scandinavian journal of infectious diseases 20070713 1

This study has verified the spread of ST-7 serogroup C meningococci in China and characterized this new clone using porA typing and comparative genomic hybridization (CGH) analysis. The data would be helpful to monitor the spread of this new serogroup C meningococci sequence type clone in China and worldwide. ...[more]

PMID: 17852942

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