Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Pseudomonas aeruginosa response to odium hypochlorite antimicrobial mechanisms


ABSTRACT: In the present study, we employed Affymetrix Pseudomonas aeruginosa GeneChip arrays to investigate global gene expression profiles during the cellular response of Pseudomonas aeruginosa to sodium hypochlorite Experiment Overall Design: We calculated fold change as the ratio between the signal averages of four untreated (control) and five sodium hypochlorite-treated (experimental) cultures for 20 min exposure.

ORGANISM(S): Pseudomonas aeruginosa

SUBMITTER: Wook Chang 

PROVIDER: E-GEOD-7402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparative global transcription analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide on Pseudomonas aeruginosa.

Small David A DA   Chang Wook W   Toghrol Freshteh F   Bentley William E WE  

Applied microbiology and biotechnology 20070712 5


Disinfectants are routinely used in hospitals and health care facilities for surface sterilization. However, the mechanisms by which these disinfectants kill and the extent to which bacteria, including Pseudomonas aeruginosa, are resistant remains unclear. Consequently, P. aeruginosa nosocomial infections result in considerable casualties and economic hardship. Previously, DNA microarrays were utilized to analyze the genome-wide transcription changes in P. aeruginosa after oxidative antimicrobia  ...[more]

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