Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yukihiro Yabuta
PROVIDER: E-GEOD-74767 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nakamura Tomonori T Okamoto Ikuhiro I Sasaki Kotaro K Yabuta Yukihiro Y Iwatani Chizuru C Tsuchiya Hideaki H Seita Yasunari Y Nakamura Shinichiro S Yamamoto Takuya T Saitou Mitinori M
Nature 20160824 7618
The epiblast (EPI) is the origin of all somatic and germ cells in mammals, and of pluripotent stem cells in vitro. To explore the ontogeny of human and primate pluripotency, here we perform comprehensive single-cell RNA sequencing for pre- and post-implantation EPI development in cynomolgus monkeys (Macaca fascicularis). We show that after specification in the blastocysts, EPI from cynomolgus monkeys (cyEPI) undergoes major transcriptome changes on implantation. Thereafter, while generating gast ...[more]