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Transcription profiling of rat renal carcinogenesis model - oxidative stress-induced

ABSTRACT: An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces oxidative renal tubular damage that subsequently leads to renal cell carcinoma in rodents. Here we used gene expression microarrays to find target oncogenes in this model. Network analysis of the gene expression microarray data revealed the involvement of beta-catenin pathway in the induced cancers. Experiment Overall Design: Carcinogenesis protocol was performed using specific pathogen-free male Wistar rats or male F1 hybrid rats between Fischer344 and Brown-Norway strains. A total of 10 microarrays (Rat Genome 230 2.0; 31,999 genes; Affymetrix Inc., Santa Clara, CA) were used for the screening purpose; two for each group of untreated control, Fe-NTA treatment for 1 week, Fe-NTA treatment for 3 weeks, Fe-NTA-induced RCCs with neither peritoneal invasion nor metastasis and Fe-NTA-induced RCCs with pulmonarymetastasis.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Shinya Toyokuni 

PROVIDER: E-GEOD-7625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway.

Liu Yu-Ting YT   Shang Donghao D   Akatsuka Shinya S   Ohara Hiroki H   Dutta Khokon Kumar KK   Mizushima Katsura K   Naito Yuji Y   Yoshikawa Toshikazu T   Izumiya Masashi M   Abe Kouichiro K   Nakagama Hitoshi H   Noguchi Noriko N   Toyokuni Shinya S  

The American journal of pathology 20071130 6

Ferric nitrilotriacetate induces oxidative renal tubular damage via Fenton-reaction, which subsequently leads to renal cell carcinoma (RCC) in rodents. Here, we used gene expression microarray and array-based comparative genomic hybridization analyses to find target oncogenes in this model. At the common chromosomal region of amplification (4q22) in rat RCCs, we found ptprz1, a tyrosine phosphatase (also known as protein tyrosine phosphatase zeta or receptor tyrosine phosphatase beta) highly exp  ...[more]

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