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Transcription profiling of mouse cerebral malaria susceptible and resistant animals

ABSTRACT: Cerebral malaria (CM) is a leading cause of death in the world. Better understanding of the pathogenesis of this disease is critical for the development of novel therapies. In this work, we investigated temporal gene expression profiles in the brains of CM-susceptible and CM-resistant mice during infection with P. Berghia ANKA (PbA). In this model of CM, susceptible mice develop neurological signs by day 6 post infection while resistant mice do not develop neurological manifestations during malarial infection. Experiment Overall Design: C57/B6 (CM-susceptible) and Balb/C (CM-resistant) mice were infected with PbA. Gene expression profiles from whole brains were obtained at day 0 (uninfected), day 1, day 3, and day 6.

ORGANISM(S): Mus musculus

SUBMITTER: Sina Gharib

PROVIDER: E-GEOD-7814 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria.

Lovegrove Fiona E FE Gharib Sina A SA Patel Samir N SN Hawkes Cheryl A CA Kain Kevin C KC Liles W Conrad WC

The American journal of pathology 20071108 6

Specific local brain responses, influenced by parasite sequestration and host immune system activation, have been implicated in the development of cerebral malaria. This study assessed whole-brain transcriptional responses over the course of experimental cerebral malaria by comparing genetically resistant and susceptible inbred mouse strains infected with Plasmodium berghei ANKA. Computational methods were used to identify differential patterns of gene expression. Overall, genes that showed the ...[more]

PMID: 17991715

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Transcriptional Profiling of Cerebral Malaria

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