Unknown,Transcriptomics,Genomics,Proteomics

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An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Jeanette Baran-Gale 

PROVIDER: E-GEOD-78169 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells.

Baran-Gale Jeanette J   Purvis Jeremy E JE   Sethupathy Praveen P   Sethupathy Praveen P  

RNA (New York, N.Y.) 20160818 10


Estrogen receptor α (ERα) is an important biomarker of breast cancer severity and a common therapeutic target. In response to estrogen, ERα stimulates a dynamic transcriptional program including both coding and noncoding RNAs. We generate a fine-scale map of expression dynamics by performing a temporal profiling of both messenger RNAs (mRNAs) and microRNAs (miRNAs) in MCF-7 cells (an ER+ model cell line for breast cancer) in response to estrogen stimulation. We identified three primary expressio  ...[more]

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