Modeling the ESR1 tyrosine 537 mutation with CRISPR-Cas9 for mechanistic studies and evaluation of therapeutic approaches for metastatic breast cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Van Nguyen
PROVIDER: E-GEOD-78286 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic modelling of the ESR1 Y537S mutation for evaluating function and new therapeutic approaches for metastatic breast cancer.
Harrod A A Fulton J J Nguyen V T M VTM Periyasamy M M Ramos-Garcia L L Lai C-F CF Metodieva G G de Giorgio A A Williams R L RL Santos D B DB Gomez P J PJ Lin M-L ML Metodiev M V MV Stebbing J J Castellano L L Magnani L L Coombes R C RC Buluwela L L Ali S S
Oncogene 20161017 16
Drugs that inhibit estrogen receptor-α (ER) activity have been highly successful in treating and reducing breast cancer progression in ER-positive disease. However, resistance to these therapies presents a major clinical problem. Recent genetic studies have shown that mutations in the ER gene are found in >20% of tumours that progress on endocrine therapies. Remarkably, the great majority of these mutations localize to just a few amino acids within or near the critical helix 12 region of the ER ...[more]
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