Unknown,Transcriptomics,Genomics,Proteomics

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Similarity of PDXs between passages and lineages using Affymetrix mRNA expression data

ABSTRACT: PDX tumors at various passages post first implantation in nude mice PDX tumors were profiled at different passages when they reached ~400mm3

ORGANISM(S): Homo sapiens

SUBMITTER: Joshua Korn 

PROVIDER: E-GEOD-78806 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.

Gao Hui H   Korn Joshua M JM   Ferretti Stéphane S   Monahan John E JE   Wang Youzhen Y   Singh Mallika M   Zhang Chao C   Schnell Christian C   Yang Guizhi G   Zhang Yun Y   Balbin O Alejandro OA   Barbe Stéphanie S   Cai Hongbo H   Casey Fergal F   Chatterjee Susmita S   Chiang Derek Y DY   Chuai Shannon S   Cogan Shawn M SM   Collins Scott D SD   Dammassa Ernesta E   Ebel Nicolas N   Embry Millicent M   Green John J   Kauffmann Audrey A   Kowal Colleen C   Leary Rebecca J RJ   Lehar Joseph J   Liang Ying Y   Loo Alice A   Lorenzana Edward E   Robert McDonald E E   McLaughlin Margaret E ME   Merkin Jason J   Meyer Ronald R   Naylor Tara L TL   Patawaran Montesa M   Reddy Anupama A   Röelli Claudia C   Ruddy David A DA   Salangsang Fernando F   Santacroce Francesca F   Singh Angad P AP   Tang Yan Y   Tinetto Walter W   Tobler Sonja S   Velazquez Roberto R   Venkatesan Kavitha K   Von Arx Fabian F   Wang Hui Qin HQ   Wang Zongyao Z   Wiesmann Marion M   Wyss Daniel D   Xu Fiona F   Bitter Hans H   Atadja Peter P   Lees Emma E   Hofmann Francesco F   Li En E   Keen Nicholas N   Cozens Robert R   Jensen Michael Rugaard MR   Pryer Nancy K NK   Williams Juliet A JA   Sellers William R WR  

Nature medicine 20151019 11

Profiling candidate therapeutics with limited cancer models during preclinical development hinders predictions of clinical efficacy and identifying factors that underlie heterogeneous patient responses for patient-selection strategies. We established ∼1,000 patient-derived tumor xenograft models (PDXs) with a diverse set of driver mutations. With these PDXs, we performed in vivo compound screens using a 1 × 1 × 1 experimental design (PDX clinical trial or PCT) to assess the population responses  ...[more]

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