Unknown,Transcriptomics,Genomics,Proteomics

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Microarray analysis of CD14+ CD163high CD160high cells in human intestinal lamina propria and CX3CR1high CD11b+ CD11c+ cells in murine intestinal lamina propria


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Daisuke Okuzaki 

PROVIDER: E-GEOD-79629 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of a human intestinal myeloid cell subset that regulates gut homeostasis.

Barman Soumik S   Kayama Hisako H   Okuzaki Daisuke D   Ogino Takayuki T   Osawa Hideki H   Matsuno Hiroshi H   Mizushima Tsunekazu T   Mori Masaki M   Nishimura Junichi J   Takeda Kiyoshi K  

International immunology 20160715 11


Inappropriate activation of T helper (Th) cells, such as Th1 and Th17 cells, is implicated in the pathogenesis of chronic inflammatory disorders including ulcerative colitis (UC). CX<sub>3</sub>CR1<sup>high</sup> macrophages contribute to intestinal homeostasis through various mechanisms in mice. However, whether mononuclear phagocytes with regulatory functions are present in the human colon is not clearly defined. We investigated whether innate myeloid cells that suppress activation of effector  ...[more]

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