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White adipose tissue browning in the R6/2 mouse model of Huntington's disease

ABSTRACT: We investigated gene expression signatures in subcutaneous inguinal adipose tissue obtained from wild type and R6/2 mice with the aim to identify gene expression changes and signalling pathway alterations in adipose tissue relevant to HD. Gene expression was assessed using Affymetrix GeneChipÂ® Mouse Gene 2.0 ST Array. Target genes were technically validated using real-time quantitative PCR. 12 subcutaneous inguinal white adipose tissue samples were analyzed by affymetrix: 6 wild-type samples; 6 R6/2 mouse samples.

ORGANISM(S): Mus musculus

SUBMITTER: Maria BjÃ¶rkqvist

PROVIDER: E-GEOD-79711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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White adipose tissue browning in the R6/2 mouse model of Huntington's disease

Project description:We investigated gene expression signatures in subcutaneous inguinal adipose tissue obtained from wild type and R6/2 mice with the aim to identify gene expression changes and signalling pathway alterations in adipose tissue relevant to HD. Gene expression was assessed using Affymetrix GeneChip® Mouse Gene 2.0 ST Array. Target genes were technically validated using real-time quantitative PCR.

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