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Response to low-dose cortisol treatment in zebrafish embryos [larvae]

ABSTRACT: Chronic early life stress increases adult susceptibility to numerous health problems linked to chronic inflammation. One way that this may occur is via glucocorticoid-induced developmental programming. To gain insight into such programming we treated zebrafish embryos with 1 micromolar cortisol and examined the effects on larvae. Treated larvae had elevated whole-body cortisol and glucocorticoid signaling, and up-regulated genes associated with defense response and immune system processes. 6 samples total were analyzed. 3 DMSO controls, and 3 cortisol treated (1 micromolar).

ORGANISM(S): Danio rerio

SUBMITTER: Benjamin King

PROVIDER: E-GEOD-80221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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