Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Sunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland


ABSTRACT: Background : In lactating cow, a sunflower oil supplementation modulated the milk composition and the mammary genes expression whose mechanisms of regulations are unclear. Results : This lipid supplementation provoke, in mammary gland, the down regulation of microRNA miR-20a-5p and miR-142-5p, which are predicted to target genes previously determined as differentially expressed including those involved in lipid metabolism. Conclusion : Those two miRNA are good candidates to explain lipogenic genes regulations after sunflower oil supplementation. Significance : The current study clarified the nutriregulation of miRNA in the mammary gland. MiRNomes obtained by NGS sequencing of mammary gland of Holstein cows at the peak of lactation received a low forage diet supplemented or not with 4% of sunflower oil were compared. MiRNA differentially expressed confirmed by RT-qPCR were related to differentially expressed genes list previously identified in the same samples.

ORGANISM(S): Bos taurus

SUBMITTER: Sylvain Marthey 

PROVIDER: E-GEOD-81616 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2016-07-01 | GSE81616 | GEO
| PRJNA322088 | ENA
2017-11-09 | GSE86024 | GEO
| 2260465 | ecrin-mdr-crc
2017-11-09 | GSE86025 | GEO
2009-11-29 | GSE11592 | GEO
2015-07-01 | GSE61025 | GEO
2021-09-09 | PXD022131 | Pride
2015-07-01 | E-GEOD-61025 | biostudies-arrayexpress
2024-08-09 | GSE274379 | GEO