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Differentiation and specification of resident tissue macrophages

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Christoph Bock

PROVIDER: E-GEOD-81774 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Specification of tissue-resident macrophages during organogenesis.

Mass Elvira E Ballesteros Ivan I Farlik Matthias M Halbritter Florian F Günther Patrick P Crozet Lucile L Jacome-Galarza Christian E CE Händler Kristian K Klughammer Johanna J Kobayashi Yasuhiro Y Gomez-Perdiguero Elisa E Schultze Joachim L JL Beyer Marc M Bock Christoph C Geissmann Frederic F

Science (New York, N.Y.) 20160804 6304

Tissue-resident macrophages support embryonic development and tissue homeostasis and repair. The mechanisms that control their differentiation remain unclear. We report here that erythro-myeloid progenitors in mice generate premacrophages (pMacs) that simultaneously colonize the whole embryo from embryonic day 9.5 in a chemokine-receptor-dependent manner. The core macrophage program initiated in pMacs is rapidly diversified as expression of transcriptional regulators becomes tissue-specific in e ...[more]

PMID: 27492475

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