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Single cell RNA-sequencing of retinal bipolar cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Karthik Shekhar

PROVIDER: E-GEOD-81905 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.

Shekhar Karthik K Lapan Sylvain W SW Whitney Irene E IE Tran Nicholas M NM Macosko Evan Z EZ Kowalczyk Monika M Adiconis Xian X Levin Joshua Z JZ Nemesh James J Goldman Melissa M McCarroll Steven A SA Cepko Constance L CL Regev Aviv A Sanes Joshua R JR

Cell 20160801 5

Patterns of gene expression can be used to characterize and classify neuronal types. It is challenging, however, to generate taxonomies that fulfill the essential criteria of being comprehensive, harmonizing with conventional classification schemes, and lacking superfluous subdivisions of genuine types. To address these challenges, we used massively parallel single-cell RNA profiling and optimized computational methods on a heterogeneous class of neurons, mouse retinal bipolar cells (BCs). From ...[more]

PMID: 27565351

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