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The Î²-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

ABSTRACT: In pediatric glioma cell lines, treatment with ICG-001 had no inhibitory effect on canonical Wnt-target genes but induced significant up regulation of various known Î²-catenin target genes in both cell lines and top 20 GO-annotations of down-regulated genes by ICG-001 were associated with biosynthetic and metabolic processes and cell cycle division processes. Pediatric cell lines were treated with ICG-001 or DMSO for 48h

ORGANISM(S): Homo sapiens

SUBMITTER: Gabriela Salinas-Riester

PROVIDER: E-GEOD-83266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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