Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jurian Schuijers
PROVIDER: E-GEOD-84456 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Schuijers Jurian J Junker Jan Philipp JP Mokry Michal M Hatzis Pantelis P Koo Bon-Kyoung BK Sasselli Valentina V van der Flier Laurens G LG Cuppen Edwin E van Oudenaarden Alexander A Clevers Hans H
Cell stem cell 20150122 2
The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and in many other adult organs. The transcription factor Ascl2 (a Wnt target gene) is a master regulator of intestinal stem cell identity. It is unclear how the continuous Wnt gradient along the crypt axis is translated into discrete expression of Ascl2 and discrete specification of stem cells at crypt bottoms. We show that (1) Ascl2 is regulated in a direct autoactivatory loop, leading to a distinct on/off expres ...[more]