Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Ascl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Jurian Schuijers 

PROVIDER: E-GEOD-84457 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and in many other adult organs. The transcription factor Ascl2 (a Wnt target gene) is a master regulator of intestinal stem cell identity. It is unclear how the continuous Wnt gradient along the crypt axis is translated into discrete expression of Ascl2 and discrete specification of stem cells at crypt bottoms. We show that (1) Ascl2 is regulated in a direct autoactivatory loop, leading to a distinct on/off expres  ...[more]

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