Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Stefan Pfister
PROVIDER: E-GEOD-8738 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Remke Marc M Pfister Stefan S Kox Corinne C Toedt Grischa G Becker Natalia N Benner Axel A Werft Wiebke W Breit Stephen S Liu Shuangyou S Engel Felix F Wittmann Andrea A Zimmermann Martin M Stanulla Martin M Schrappe Martin M Ludwig Wolf-Dieter WD Bartram Claus R CR Radlwimmer Bernhard B Muckenthaler Martina U MU Lichter Peter P Kulozik Andreas E AE
Blood 20090430 5
Precursor T-cell acute lymphoblastic leukemia (T-ALL) in children represents a clinical challenge, because relapses are usually fatal. It is thus necessary to identify high-risk patients as early as possible to effectively individualize treatment. We aimed to define novel molecular risk markers in T-ALL and performed array-based comparative genomic hybridization (array-CGH) and expression analyses in 73 patients. We show that DNA copy-number changes are common in T-ALL and affect 70 of 73 (96%) ...[more]