Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER:
PROVIDER: E-BUGS-86 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Alice H AH Waddell Simon J SJ Hinds Jason J Malloff Chad A CA Bains Manjeet M Hancock Robert E RE Lam Wan L WL Butcher Philip D PD Stokes Richard W RW
PloS one 20100610 6
<h4>Background</h4>H37Rv and H37Ra are well-described laboratory strains of Mycobacterium tuberculosis derived from the same parental strain, H37, that show dramatically different pathogenic phenotypes.<h4>Methodology/principal findings</h4>In this study, the transcriptomes of the two strains during axenic growth in broth and during intracellular growth within murine bone-marrow macrophages were compared by whole genome expression profiling. We identified and compared adaptations of either strai ...[more]