Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling by array of Mycobacterium tuberculosis virulent and attenuated strains infecting macrophages


ABSTRACT: Data is also available from BuG@Sbase

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER:  

PROVIDER: E-BUGS-86 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages.

Li Alice H AH   Waddell Simon J SJ   Hinds Jason J   Malloff Chad A CA   Bains Manjeet M   Hancock Robert E RE   Lam Wan L WL   Butcher Philip D PD   Stokes Richard W RW  

PloS one 20100610 6


<h4>Background</h4>H37Rv and H37Ra are well-described laboratory strains of Mycobacterium tuberculosis derived from the same parental strain, H37, that show dramatically different pathogenic phenotypes.<h4>Methodology/principal findings</h4>In this study, the transcriptomes of the two strains during axenic growth in broth and during intracellular growth within murine bone-marrow macrophages were compared by whole genome expression profiling. We identified and compared adaptations of either strai  ...[more]

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