Genetic alteration in recurrent melanoma - part 2

ABSTRACT: Studying a unique case of metastatic melanoma, we observed that cell lines derived from metachronous metastases arising over a decade retained a central core of genetic stability in spite of divergent phenotypes. In the present study we expanded our previous observations comparing these autologous cell lines of clonal derivation with heterologous ones and correlated array Comparative Genomic Hybridization with gene expression profiling to determine their relative contribution to the dynamics of disease progression. aCGH and gene expression profiling were performed on autologous cell lines and heterologous melanoma cell lines originated from other patients. A striking correlation existed between total extent of genetic imbalances, global transcriptional patterns and cellular phenotypes; the

ORGANISM(S): Homo sapiens

SUBMITTER: Francesco Marincola 

PROVIDER: E-GEOD-8778 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress