Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human colorectal carcinoma-derived cell lines, p53 -/-, +/-, +/+ at 0 and 12 hrs after growth arrest


ABSTRACT: Human colorectal carcinoma-derived cell lines, p53 -/-, +/-, +/+ at 0 and 12 hrs after growth arrest.

ORGANISM(S): Homo sapiens

SUBMITTER: Fred Wright 

PROVIDER: E-GEOD-90 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53.

Yoon Heejei H   Liyanarachchi Sandya S   Wright Fred A FA   Davuluri Ramana R   Lockman Janet C JC   de la Chapelle Albert A   Pellegata Natalia S NS  

Proceedings of the National Academy of Sciences of the United States of America 20021115 24


TP53 does not fully comply with the Knudson model [Knudson, A. G., Jr. (1971) Proc. Natl. Acad. Sci. USA 68, 820-823] in that a reduction of constitutional expression of p53 may be sufficient for tumor predisposition. This finding suggests a gene-dosage effect for p53 function. To determine whether TP53 gene dosage affects the transcriptional regulation of target genes, we performed oligonucleotide-array gene expression analysis by using human cells with wild-type p53 (p53 +/+), or with one (p53  ...[more]

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