Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Fred Wright
PROVIDER: E-GEOD-90 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Yoon Heejei H Liyanarachchi Sandya S Wright Fred A FA Davuluri Ramana R Lockman Janet C JC de la Chapelle Albert A Pellegata Natalia S NS
Proceedings of the National Academy of Sciences of the United States of America 20021115 24
TP53 does not fully comply with the Knudson model [Knudson, A. G., Jr. (1971) Proc. Natl. Acad. Sci. USA 68, 820-823] in that a reduction of constitutional expression of p53 may be sufficient for tumor predisposition. This finding suggests a gene-dosage effect for p53 function. To determine whether TP53 gene dosage affects the transcriptional regulation of target genes, we performed oligonucleotide-array gene expression analysis by using human cells with wild-type p53 (p53 +/+), or with one (p53 ...[more]