Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

31 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse tumors from H. hepaticus infected animals vs. infected and control mice

ABSTRACT: We are investigating the transcriptional response of mice infected with Helicobacter hepaticus and links to liver cancer; We used microarrays to detail the global programme of gene expression underlying H. hepaticus induced liver cancer Experiment Overall Design: Mice with tumors were compared to mice with infection only (comparison 2) and mice infected were compared to control mice (comparison 1)

ORGANISM(S): Mus musculus

SUBMITTER: Rebecca Fry

PROVIDER: E-GEOD-9097 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of mouse Male A/JCr mice were inoculated with H. hepaticus or vehicle at 4 weeks some underwent castration at 1 year

Project description:We are investigating hepatic transcriptional responses associated with castration and tumorigenic hepatitis induced by Helicobacter hepaticus infection in mature male A/JCr mice; Microarray data demonstrated a global loss of gender-dimorphic gene expression regulation in mice with chronic hepatitis and liver cancer Experiment Overall Design: Male A/JCr mice were inoculated with H. hepaticus or vehicle at 4 weeks; some underwent castration at 1 year, and all were necropsied at 21 months

2008-06-15 | E-GEOD-6632 | biostudies-arrayexpress

H. hepaticus infection and liver cancer

Project description:We are investigating the transcriptional response of mice infected with Helicobacter hepaticus and links to liver cancer We used microarrays to detail the global programme of gene expression underlying H. hepaticus induced liver cancer Keywords: disease model

2007-11-01 | GSE9097 | GEO

Transcription profiling of mouse liver and cecum after exposure to aflatoxin B1 (AFB1) and/or Helicobacter hepaticus

Project description:We evaluated aflatoxin B1-induced liver tumor promotion by H. hepaticus. Microarrays of liver and cecum from female mice were used to evaluate the individual and combined transcriptional effects of AFB1 and H. hepaticus Experiment Overall Design: C3H/HeN mice were inoculated with 7 ug/g BW AFB1 or vehicle IP at 10 days of age, and gavaged with H. hepaticus or broth at 3 weeks; necropsied at 40 weeks

2008-06-20 | E-GEOD-11382 | biostudies-arrayexpress

fliA regulon of Helicobacter hepaticus

Project description:Differential gene regulation in Helicobacter hepaticus between wild type bacteria and fliA mutant

2009-07-14 | GSE12123 | GEO

Transcriptome profiling of gene expression in the colon tissues of steady state and Helicobacter hepaticus-infected 129SvEvS6.Rag2−/− mice and the congenic strain 129.C3B.Rag2−/− R17

Project description:Chronic inflammation of the intestine has been associated with an elevated risk of developing colorectal cancer. Recent association studies have highlighted the role of genetic predisposition in the etiology of colitis and started to unravel its complexity. However, the genetic factors influencing the progression from colon inflammation to tumorigenesis are not known. We used Helicobacter hepaticus-induced colitis in a 129.RAG(-/-) mouse model to explore early onset of the disease. Experiments purpose and justifications: to elucidate early genes and pathways changed in the mouse strain susceptible to innate colitis triggered by Hh infection. Experimental factors: steady state, and days 2 and 4 of infection (n=4 mice per condition). The time course is validated on the same samples using qPCR for inflammatory genes. Samples: RNA from proximal mouse colon. Two mouse genetic strains are compared 129Rag-/- (susceptible) and 129.R17Rag-/- (protected from colitis).

2018-07-30 | E-MTAB-7075 | biostudies-arrayexpress

Helicobacter hepaticus

Project description:fliA regulon of Helicobacter hepaticus

| PRJNA113781 | ENA

fliA regulon of Helicobacter hepaticus

Project description:Differential gene regulation in Helicobacter hepaticus between wild type bacteria and fliA mutant 3 biological experiments of both wild type and fliA mutant bacteria (1-3) and 2 replicates (dye flip) of each biological experiment

2009-07-14 | E-GEOD-12123 | biostudies-arrayexpress

Quantitative proteogenomic characterization of inflamed murine colon tissue using an integrated discovery, verification, and validation proteogenomic workflow

Project description:Rag2-/-Il10-/- mice were subjected to infection by Helicobacter hepaticus and allowed to develop long-term infections. Proximal colon tissue was then harvested from the mice for analysis. RNA was isolated from the samples and submitted for transcriptomic analysis; this data was then used to create a custom RNA-based FASTA database. Protein isolated from the proximal colon samples were digested and analyzed via bottom-up mass spectrometry. The custom FASTA database was then used for proteogenomic analysis of the raw mass spectrometry data in the Galaxy for proteomics (Galaxy-P) platform.

2022-05-19 | PXD028407 | Pride

Liver and cecum from mice exposed to aflatoxin B1 (AFB1) and/or Helicobacter hepaticus

2008-05-09 | GSE11382 | GEO

Microarray analysis of bone-marrow derived macrophages (BMDMs) stimulated with two different TLR2 agonists, H. hepaticus polysaccharide or Pam3CSK4

Project description:Identification of pro- and anti-inflammatory pathways induced in M-CSF differentiated bone-marrow derived macrophages (BMDMs) after 3 h stimulation with two different TLR2 agonists, Helicobacter hepaticus polysacharide and Pam3CSK4 (75 ng/ml), using TSB (Tryptone Soya Broth) medium as a control

2017-08-25 | E-MTAB-5780 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data