Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse adipose tissue from lipodystrophic mice

ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE9130: aP2-nSREBP1c_white_Adipose_Tissue_expression_differentials; GSE9131: Pparg_white_Adipose_Tissue_expression_differentials Experiment Overall Design: Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Yaacov Barak

PROVIDER: E-GEOD-9132 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

A mouse model of conditional lipodystrophy.

Kim Suyeon S Huang Li-Wen LW Snow Kathy J KJ Ablamunits Vitaly V Hasham Muneer G MG Young Timothy H TH Paulk Angelique C AC Richardson Joel E JE Affourtit Jason P JP Shalom-Barak Tali T Bult Carol J CJ Barak Yaacov Y

Proceedings of the National Academy of Sciences of the United States of America 20071005 42

Lipodystrophies are syndromes of adipose tissue degeneration associated with severe defects in lipid and glucose homeostasis. We report here the generation and analysis of Pparg(ldi), a targeted allele that confers conditional dominant lipodystrophy in mice. The Pparg(ldi) allele was generated by insertion of the Tet activator (tTA) and a tTA-regulated Flag-Pparg1 transgene into the Pparg gene. Unexpectedly, tTA elicits mild lipodystrophy, insulin resistance, and dyslipidemia, and the Flag-PPARg ...[more]

PMID: 17921248

Similar Datasets

Transcription profiling of mouse adipose tissue from Pparg<ldi/+> animals

Project description:Identifying gene expression changes in adipose tissue of lipodystrophic Pparg<ldi/+> targeted mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old Pparg<ldi/+> males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ?¢ arrays, one mouse per array.

2008-06-16 | E-GEOD-9131 | biostudies-arrayexpress

Transcription profiling of mouse adipose tissue of lipodystrophic aP2-nSREBP1c trangenic animals

Project description:Identifying gene expression changes in adipose tissue of lipodystrophic aP2-nSREBP1c trangenic mice Experiment Overall Design: RNA from epididymal white adipose pads of three 10-week-old aP2-nSREBP1c transgenic males and three litter-matched WT controls was analyzed by MOE430v2.0 GeneChipâ¢ arrays, one mouse per array.

2008-06-17 | E-GEOD-9130 | biostudies-arrayexpress

White adipose tissue from aP2-Pex5 knockout and control mice

Project description:These arrays contain data from gonodal adipose tissue of aP2-Pex5 -/- male mice 4 arrays from gonadal adipose tissue from control mice (Swiss background) are compared with 4 arrays from gonadal adipose tissue of aP2-Pex5 knockout mice. The latter lack functional peroxisomes in adipose tissue.

2012-03-01 | E-GEOD-31940 | biostudies-arrayexpress

PPARγ is a major driver of the accumulation and phenotype of adipose-tissue Treg cells

Project description:This SuperSeries is composed of the following subset Series: GSE37532: Gene expression profile of regulatory T cells (Tregs) isolated from visceral adipose tissue and lymph nodes of mice sufficient and deficient of Pparg expression in Tregs GSE37533: Expression data of Pioglitazone- or vehicle-treated CD4+FoxP3- T cells transduced with Foxp3+/- Pparg1 (or Pparg2) GSE37534: Expression data of Pioglitazone-, Rosiglitazone-, GW1929- and vehicle-treated CD4+FoxP3- T cells transduced with Foxp3+Pparg1 Refer to individual Series

2012-05-03 | E-GEOD-37535 | biostudies-arrayexpress

White adipose tissue from aP2-Pex5 knockout and control mice

Project description:These arrays contain data from gonodal adipose tissue of aP2-Pex5 -/- male mice

2012-03-01 | GSE31940 | GEO

Transcription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

Project description:This SuperSeries is composed of the following subset Series:; GSE5388: Adult postmortem brain tissue (dorsolateral prefrontal cortex) in subjects with bipolar disorder; GSE5389: Adult postmortem brain tissue (ortibtofrontal cortex) in subjects with bipolar disorder; Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Experiment Overall Design: Refer to individual Series

2008-06-13 | E-GEOD-5392 | biostudies-arrayexpress

Expression data from the adipose tissue of mice fed a normal diet and a high fat diet.

Project description:To identify novel Peroxisome Proliferator-Activated Receptor gamma (PPARg) responsive secretory and/or transmembrane genes that is related to obesity, we integrated the expression data from the adipose tissue derived from obese mice with the other two data sets: expression profiling of adipocyte differentiation using ST2 cells and siRNA-mediated knockdown of Pparg during ST2 cell adipogenesis. We used microarrays to detect the up-regulated genes in adipose tissue derived from mice fed a high fat diet compared to a control. Total RNA from adipose tissue was obtained and from mice fed a high fat diet HFD32 (MOUSE_HFD) from 6 week-old to 18 week-old, or a normal diet CE-2 (MOUSE_ND) as a control. Pooled RNAs of each three animals were analyzed by the Affymetrix GeneChip microarray system.

2013-01-30 | E-GEOD-36492 | biostudies-arrayexpress

Licensing of PPARg-regulated gene expression by IL-4-induced alternative macrophage activation

Project description:This SuperSeries is composed of the following subset Series: GSE16385: Expression data from human macrophages GSE16386: Expression data from human alternatively activated macrophages GSE25088: PPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived macrophages GSE25123: PPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived macrophages GSE25125: PPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived alternatively activated macrophages and immature dendritic cells (iDCs) Refer to individual Series

2010-11-18 | E-GEOD-16387 | biostudies-arrayexpress

Expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes

Project description:This SuperSeries is composed of the following subset Series: GSE17058: MiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes GSE17059: Gene expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes Refer to individual Series

2010-05-16 | E-GEOD-17060 | biostudies-arrayexpress

Gene expression profile of regulatory T cells (Tregs) isolated from visceral adipose tissue and lymph nodes of mice sufficient and deficient of Pparg expression in Tregs

Project description:We identified Pparg as a major orchestrator of the phenotype of adipose-tissue resident regulatory T cells (VAT Tregs). To establish the role of Pparg in shaping the VAT Tregs gene profile and cell dynamics, Tregs from lymph nodes and visceral adipose tissue of mice sufficient and deficient of Pparg expression in Tregs were double sorted for microarray analysis. All gene expression profiles were obtained from highly purified (double-sorted) T cell populations sorted by flow cytometry. To reduce variability, cells from multiple mice were pooled. Triplicates were generated for all groups. Raw data were preprocessed with the RMA algorithm in GenePattern and averaged expression values were used for analysis.

2012-05-03 | E-GEOD-37532 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data