Dataset Information
Transcription profiling of mouse neonatal mouse cardiomyocyte to investigate the effect of LAMR1-TP1 - INCOMPLETE DATASET
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yoshihiro Asano
PROVIDER: E-GEOD-927 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Lamr1 functional retroposon causes right ventricular dysplasia in mice.
Nature genetics 20040118 2
Arrhythmogenic right ventricular dysplasia (ARVD) is a hereditary cardiomyopathy that causes sudden death in the young. We found a line of mice with inherited right ventricular dysplasia (RVD) caused by a mutation of the gene laminin receptor 1 (Lamr1). This locus contained an intron-processed retroposon that was transcribed in the mice with RVD. Introduction of a mutated Lamr1 gene into normal mice by breeding or by direct injection caused susceptibility to RVD, which was similar to that seen i ...[more]
