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Transcription profiling of mouse kideney FROM beta catenin deficient animals vs controls AT E12.5

ABSTRACT: We generated a murine genetic model of beta-catenin deficiency targeted to the ureteric bud cell lineage to study the role of beta-catenin mediated Wnt signaling during ureteric morphogenesis. Experiment Overall Design: A comparison was made between triplicate samples of E12.5 kidneys from either normal mice or mice with a b-catenin allele containing LoxP sites flanking exons 2 through 6 crossed to Hoxb7-Cre:Gfp mice

ORGANISM(S): Mus musculus

SUBMITTER: Brian Joseph Cox 

PROVIDER: E-GEOD-9629 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Canonical WNT/beta-catenin signaling is required for ureteric branching.

Bridgewater Darren D   Cox Brian B   Cain Jason J   Lau Agnes A   Athaide Valerie V   Gill Paul S PS   Kuure Satu S   Sainio Kirsi K   Rosenblum Norman D ND  

Developmental biology 20080221 1

WNT/beta-catenin signaling has an established role in nephron formation during kidney development. Yet, the role of beta-catenin during ureteric morphogenesis in vivo is undefined. We generated a murine genetic model of beta-catenin deficiency targeted to the ureteric bud cell lineage. Newborn mutant mice demonstrated bilateral renal aplasia or renal dysplasia. Analysis of the embryologic events leading to this phenotype revealed that abnormal ureteric branching at E12.5 precedes histologic abno  ...[more]

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