Dataset Information

The beta-catenin interactome in a vascular smooth muscle cell model

ABSTRACT: Canonical Wnt/β-catenin signalling is an essential regulator of various cellular functions throughout development and adulthood. Aberrant Wnt/β-catenin signalling also contributes to various pathologies including cancer, necessitating an understanding of cell context dependent mechanisms regulating this pathway. Since protein-protein interactions underpin β-catenin function and localization, we sought to identify novel β-catenin interacting partners by affinity purification coupled with tandem mass spectrometry in vascular smooth muscle cells (VSMCs), where β-catenin is involved in both physiological and pathological control of cell proliferation. Here, we report novel components of the VSMC β-catenin interactome.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart, Vascular Associated Smooth Muscle Cell, Cardiac Muscle Cell

DISEASE(S): Coronary Restenosis

SUBMITTER: Declan Williams

LAB HEAD: John C. McDermott

PROVIDER: PXD010421 | Pride | 2018-10-25

REPOSITORIES: Pride

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Source:

			Action	DRS
	A10_BetaCateninImmunoprecipitate1.msf	Msf
	A10_BetaCateninImmunoprecipitate1.raw	Raw
	A10_BetaCateninImmunoprecipitate2.msf	Msf
	A10_BetaCateninImmunoprecipitate2.raw	Raw
	A10_BetaCateninImmunoprecipitate3.msf	Msf

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The beta-catenin interactome in a vascular smooth muscle cell model

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