The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Doris Steinemann
PROVIDER: E-GEOD-9821 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97.
Bertram Catharina C von Neuhoff Nils N Skawran Britta B Steinemann Doris D Schlegelberger Brigitte B Hass Ralf R
BMC cell biology 20080215
<h4>Background</h4>Retrodifferentiation and regained proliferative capacity of growth-arrested human leukemic cells after monocyte-like differentiation requires proteolytic activities together with distinct regulatory factors. The AAA ATPase valosin-containing protein (VCP/p97) contributes to protein degradation and cell cycle regulation, respectively, and it was of interest to study a possible role of VCP/p97 during this myelomonocytic differentiation and retrodifferentiation.<h4>Results</h4>Se ...[more]
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