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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human hMADS cells during adipocyte and osteoblast differentiation

ABSTRACT: human adipocyte and osteoblast differentiation of hMADS cells

ORGANISM(S): Homo sapiens

SUBMITTER: Zlatko Trajanoski

PROVIDER: E-MARS-10 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis.

Scheideler Marcel M Elabd Christian C Zaragosi Laure-Emmanuelle LE Chiellini Chiara C Hackl Hubert H Sanchez-Cabo Fatima F Yadav Sunaina S Duszka Kalina K Friedl Gerald G Papak Christine C Prokesch Andreas A Windhager Reinhard R Ailhaud Gerard G Dani Christian C Amri Ez-Zoubir EZ Trajanoski Zlatko Z

BMC genomics 20080717

<h4>Background</h4>A reciprocal relationship between bone and fat development in osteoporosis is clinically well established. Some of the key molecular regulators involved in this tissue replacement process have been identified. The detailed mechanisms governing the differentiation of mesenchymal stem cells (MSC) - the key cells involved - are however only now beginning to emerge. In an attempt to address the regulation of the adipocyte/osteoblast balance at the level of gene transcription in a ...[more]

PMID: 18637193

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