Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype


ABSTRACT: We analyzed bone marrow samples of 31 children with acute lymphoblastic leukemia to identify changes in gene expression that are associated with the current risk assignment, irrespective of the genetic subtype

ORGANISM(S): Homo sapiens

SUBMITTER: Beat Schafer 

PROVIDER: E-MEXP-120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Gene expression profiles and risk stratification in childhood acute lymphoblastic leukemia.

Teuffel Oliver O   Dettling Marcel M   Cario Gunnar G   Stanulla Martin M   Schrappe Martin M   Bühlmann Peter P   Niggli Felix K FK   Schäfer Beat W BW  

Haematologica 20040701 7


<h4>Background and objectives</h4>Childhood acute lymphoblastic leukemia (ALL) is a heterogeneous disease. There are several distinct genetic subtypes, characterized by typical changes in gene expression pattern. In addition to cytogenetic markers, the in vivo response to treatment is an emerging prognostic marker for risk stratification. However, it has not yet been reported whether gene expression profiles can predict risk group stratification already at the time of diagnosis.<h4>Design and me  ...[more]

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