Dataset Information
Comparative genomic hybridization of human osteosarcoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): Osteosarcoma
SUBMITTER: Stine Kresse
PROVIDER: E-MEXP-1219 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization.
Genes, chromosomes & cancer 20090801 8
Osteosarcomas are the most common primary malignant tumor of bone, and almost all conventional osteosarcomas are high-grade tumors with complex karyotypes. We have examined DNA copy number changes in 36 osteosarcoma tumors and 20 cell lines using microarray-based comparative genomic hybridization. The most frequent minimal recurrent regions of gain identified in the tumor samples were in 1q21.2-q21.3 (78% of the samples), 1q21.3-q22 (78%), and 8q22.1 (72%). Minimal recurrent regions in 10q22.1-q ...[more]
