Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jose Yelamos
PROVIDER: E-MEXP-1237 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Saenz Luis L Lozano Juan J JJ Valdor Rut R Baroja-Mazo Alberto A Ramirez Pablo P Parrilla Pascual P Aparicio Pedro P Sumoy Lauro L Yélamos José J
BMC genomics 20080416
<h4>Background</h4>Accumulating evidence suggests an important role for the enzyme poly(ADP-ribose) polymerase-1 (PARP-1) as an integral part of the gene expression regulatory machinery during development and in response to specific cellular signals. PARP-1 might modulate gene expression through its catalytic activity leading to poly(ADP-ribosyl)ation of nuclear proteins or by its physical association with relevant proteins. Recently, we have shown that PARP-1 is activated during T cell activati ...[more]