Transcription profiling of liver from mice expressing or not expressing the p16INK4a gene
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Uwe Ueberham
PROVIDER: E-MEXP-1264 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli.
Ueberham Elke E Lindner Ricco R Kamprad Manja M Hiemann Rico R Hilger Nadja N Woithe Barbara B Mahn Doris D Cross Michael M Sack Ulrich U Gebhardt Rolf R Arendt Thomas T Ueberham Uwe U
Journal of cellular and molecular medicine 20071205 2
Terminal differentiation requires molecules also involved in aging such as the cell cycle inhibitor p16(INK4a). Like other organs, the adult liver represents a quiescent organ with terminal differentiated cells, hepatocytes and cholangiocytes. These cells retain the ability to proliferate in response to liver injury or reduction of liver mass. However, under conditions which prevent mitotic activation of hepatocytes, regeneration can occur instead from facultative hepatic stem cells.For therapeu ...[more]
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